Results Spontaneous paresis of White Leghorns is caused by cell-mediated, inflammatory demyelination affecting multiple cranial and spinal nerves and nerve roots with a proximodistal tapering. ![]() These investigations were accomplished by MHC genotyping and a PCR screen for Marek's disease virus (MDV. The cytokine expression pattern was assessed by quantitative real-time PCR (qRT-PCR. Infiltrating cells were phenotyped immunohistologically and quantified by flow cytometry. Peripheral nervous system (PNS alterations were characterised using standard morphological techniques, including nerve fibre teasing and transmission electron microscopy. Methods Neurologically affected chickens and control animals from one single flock underwent clinical and neuropathological examination. Here, we investigated in detail the immunopathology of this paretic syndrome and its possible resemblance to human neuropathies. Previously, a similar clinical syndrome has been reported as being caused by inflammatory demyelination of peripheral nerve fibres. Acute paretic syndrome in juvenile White Leghorn chickens resembles late stages of acute inflammatory demyelinating polyneuropathies in humansĭirectory of Open Access Journals (Sweden)įull Text Available Abstract Background Sudden limb paresis is a common problem in White Leghorn flocks, affecting about 1% of the chicken population before achievement of sexual maturity.
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